In vivo efficacy of tobramycin-loaded synthetic calcium phosphate beads in a rabbit model of staphylococcal osteomyelitis
Abstract Background Osteomyelitis is an acute or chronic inflammatory process of the bone following infection with pyogenic organisms like Staphylococcus aureus.Tobramycin (TOB) is a promising aminoglycoside antibiotic used to treat various bacterial infections, including S.aureus.The aim of this study was to investigate the efficacy of tobramycin-